People

Irina Alexander, PhD

Postdoctoral Fellows

Research Interests

Dr. Alexander is interested in molecular therapeutics and underlying causes of various human diseases including cancer, Alzheimer’s disease and type 2 diabetes. She is currently exploring the effect of ultra short peptides in chronic diabetic wounds and Alzheimer’s disease.

Selected Publications

  •  ​​Tumor-derived circulating endothelial cell clusters in colorectal cancer.
I. Cima, S.L. Kong, D. Sengupta, I.B. Tan,3,4 W.M. Phyo, D. Lee, M. Hu, C. Iliescu, I. Alexander, W.L. Goh, M. Rahmani, N.A.M. Suhaimi, J.H. Vo, J.A. Tai, J.H. Tan, C. Chua, R. Ten, W. J. Lim, M.H. Chew, C.A.E. Hauser, R.M. van Dam, W.Y. Lim, S. Prabhakar, B. Lim, P.K. Koh, P. Robson, J.Y. Ying, A.M. Hillmer, M.H. Tan.
Science Translational Medicine 8, 345ra89 (2016)
  • p53 Maintains Genomic Stability by Preventing Interference between Transcription and Replication​
 Yeo C, Alexander I, Lin Z, Lim s., Aning O.A., Kumar R., Sangthongpitag K, Pendhakar, Ho V.H.B, Cheok C.F.
Cell Reports 2016 Apr 5;15(1):132-46 (2016).
  • USP8-mediated deubiquitination of HIF1α under normoxia is essential for ciliogenesis​
 Troilo A* & Alexander I*, Muehl SM, Jamarillo D. Knobeloch KPK, Krek W 

 EMBO Reports 2014 Jan;15(1):77-85 (2014) *equal contribution

  • Function and mode of regulation of endothelial major histocompatibility complex class II​

Alexander I, Edelman ER, Methe H

Cell Transplantation. 18(3):255-9 (2009)

Education

  • Postdoctoral Fellow, KAUST Laboratory for Nanomedicine, Saudi Arabia, 2016 
  • Postdoctoral Fellow, A*STAR Biomedical Science Institutes, Singapore, 2014
  • Ph.D., Molecular Life Science, ETH Zurich, Switzerland, 2010
  • M.Sc., Biology & Biomedical Engineering, University of Dusseldorf, Germany / Massachusetts Institute of Technology, US, 2005