Publications 2015

​Peptide bioink: self-assembling nanofibrous scaffolds for 3d organotypic cultures
Y. Loo, A. Lakshmanan, M. Ni, L.L. Toh, S. Wang, and C.A.E. Hauser
Nano Letters 15 (2015) 6919-6925
Y. Loo, A. Lakshmanan, M. Ni, L.L. Toh, S. Wang, and C.A.E. Hauser
Bioprinting, Nanofibrous scaffold, Peptide bioink, Smart biomaterials, Stimuli-responsive self-assembly, Ultrashort peptides
2015


Printable scaffolds with adequate mechanical strength and stiffness are sought after to ensure viability of printed cells and tissues. We report the first peptide bioinks-lysine-containing hexapeptides that self-assemble into stable, nanofibrous three-dimensional hydrogels with unprecedented stiffness of up to 40 kPa. These biocompatible scaffolds support the three-dimensional culture of human stem cells and differentiation of primary cells into organotypic (gastrointestinal and skin) structures for high-throughput screening, diagnosis, and tissue engineering.



DOI: 10.1021/acs.nanolett.5b02859