Laboratory for Nanomedicine

Development of a robotic 3D bioprinting and microfluidic pumping system for tissue and organ engineering

K. Kahin, Z. Khan, M. Albagami, S. Usman, S. Bahnshal, H. Alwazani, M.A. Majid, S. Rauf, C. Hauser

Proceedings Volume 10875, Microfluidics, BioMEMS, and Medical Microsystems XVII; 108750Q, 2019

Keywords:

Robotics, 3D printing, 3D modeling, MATLAB, 3D image processing

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2019

Optimization of a 3D bioprinting process using ultrashort peptide bioinks

Z. Khan, K. Kahin, S. Rauf, G. Ramirez-Calderon, N. Papagiannis, M. Abdulmajid, C.A.E. Hauser

International Journal of Bioprinting 5(1),173, 2019

Keywords:

3D bioprinting; Ultrashort peptides; Biomaterials; Bioinks; Tissue engineering; Vacuum system

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2019

Thin peptide hydrogel membranes suitable as scaffolds for engineering layered biostructures

W.Y. Seow, K. Kandasamy, K. Purnamawati, W. Sun, C.A.E. Hauser

Acta Biomaterialia, 2019

Keywords:

Ultrashort peptide hydrogel; Disulfide bonds; Tissue engineering; Scaffolds; Layered biostructures; Membranes

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2019

Novel ultrashort self-assembling peptide bioinks for 3d culture of muscle myoblast cells
W. Arab, S. Rauf, O. Al-Harbi, C. Hauser
Open Journal Systems, 2018

Keywords:

Biomaterials, Bioinks, 3D cell culture, 3D Scaffold, Tissue engineering, Skeletal muscle cells

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2018

Evaluation of peptide nanogels for accelerated wound healing in normal micropigs

W.T. Arab, A.M. Niyas, K. Seferji, H.H. Susapto and C.A.E. Hauser

Frontiers in Nanoscience and Nanotechnology, 2018

Keywords:

Ultrashort peptides, Self-assembly, Nanogels, Chronic wounds, Dressing, Wound healing

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2018

C-Terminal residue of ultrashort peptides impacts on molecular self-assembly, hydrogelation, and interaction with small-molecule drugs

K.H. Chan, W.H. Lee, M. Ni, Y. Loo & C.A.E. Hauser

Scientific Reports, Volume 8, Article number: 17127, 2018

Keywords:

Ultrashort peptides, Molecular self-assembly, Hydrogelation, Small-molecule drugs

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2018

Towards biologically relevant synthetic designer matrices in 3D bioprinting for tissue engineering and regenerative medicine
R.M. Costa, S. Rauf, C.A.E. Hauser
Current Opinion in Biomedical Engineering, Volume 2, Pages 90-98, 2017

Keywords:

3D bioprinting, Bioinks, Synthetic scaffolds, Tissue reconstruction, Hydrogels, Scaffold functionalization, Biomedical engineering

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2017

Transparent crosslinked ultrashort peptide hydrogels as a carrier dressing with high shape fidelity to accelerate healing of full-thickness excision wounds
W.Y. Seow, G. Salgado, E.B. Lane, and C.A.E. Hauser
Scientific Reports 6 (2016), 32670

Keywords:

Peptide hydrogels, High shape fidelity, Excision wounds, Human body

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2016

Freeze-dried agarose gels: A cheap, simpe and recyclable adsorbent for the purification of methylene blue from industrial wastewater
W.Y. Seow and C.A.E. Hauser
Journal of Environmental Chemical Engineering 4 (2016) 1714-1721

Keywords:

Adsorption, Agarose hydrogel, Freeze dry, Methylene blue, Textile and industrial wastewater, Water purification

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2016

Roadmap on biosensing and photonics for nanomedicine
E. Di Fabrizio, S. Schlücker, J. Wenger, R. Regmi, H. Rigneault, G. Calafiore, M. West, S. Cabrini, M. Fleischer, N. van Hulst, M.F. Garcia-Parajo, A. Pucci, D. Cojoc, C.A.E. Hauser, and M. Ni
Journal of Optics 18 (2016) 063003

Keywords:

Biophotonics, Biosensing, Nanomedicine, Nanophotonics, Plasmonics

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2016

Bioprinting synthetic self-assembling peptide hydrogels for biomedical applications
Y. Loo and C.A.E. Hauser
Biomedical Materials 11 (2016) 014103

Keywords:

Biomaterial, Hydrogel, Nanofiber, Peptide

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2016

Probing droplets with biological colloidal suspensions on smart surfaces by synchrotron radiation micro- and nano-beams
G. Marinaro, A. Accardo, N. Benseny-Cases, M. Burghammer, H. Castillo-Michel, M. Cotte, S. Dante, F. De Angelis, E. Di Cola, E. Di Fabrizio, C. Hauser and C. Riekel
Optics and Lasers in Engineering 76 (2016) 57-63

Keywords:

Biological colloids, Digital microfluidics, Micro-/nano X-ray diffraction, MicroFTIR, Synchrotron radition

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2016

3D bioprinting technology for regenerative medicine applications
D. Sundaramurthi, S. Rauf, and C.A.E. Hauser
International Journal of Bioprinting, 2 (2016) 9-16

Keywords:

Bioprinting, Bioinks, Cells, Hydrogels, Scaffolds, Organ transplantation

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2016

Tumor-derived circulating endothelial cell clusters in colorectal cancer
I. Cima, S.L. Kong, (...), C.A.E. Hauser, R.M. van Dam, W.-Y. Lim, S. Prabhakar, B. Lim, P.K. Koh, P. Robson, J.Y. Ying, A.M. Hillmer, and M.-H. Tan
Science Translational Medicine 8 (2016) 345ra8

Keywords:

Cancer, Early detection, Colorectal cancer, Liquid biopsy, Circulating tumor cells, Translational medicine

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2016

Peptide bioink: self-assembling nanofibrous scaffolds for 3d organotypic cultures
Y. Loo, A. Lakshmanan, M. Ni, L.L. Toh, S. Wang, and C.A.E. Hauser
Nano Letters 15 (2015) 6919-6925

Keywords:

Bioprinting, Nanofibrous scaffold, Peptide bioink, Smart biomaterials, Stimuli-responsive self-assembly, Ultrashort peptides

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2015

Self-assembled proteins and peptides as scaffolds for tissue regeneration
Y. Loo, M. Göktaş, A.B. Tekinay, M.O. Guler, C.A.E. Hauser, and A. Mitraki
Advanced Healthcare Materials 4 (2015) 2557-2586

Keywords:

Peptides, Proteins, Rational design, Scaffolds, Self-assembly, Tissue engineering

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2015

Synthesis and bioactivity of a conjugate composed of green tea catechins and hyaluronic acid
F. Lee, J. Lim, M.R. Reithofer, S.S. Lee, J.E. Chung, C.A.E. Hauser and M. Kurisawa
Polymer Chemistry, 6 (2015) 4462-4472

Keywords:

Bioactivity; Biocompatibility; Isomers; Mass spectrometry, Nuclear magnetic resonance spectroscopy, Organic acids, Tissue engineering

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2015

The wonder stuff – How peptide hydrogels could change the face of biomedicine
K.H. Chan, Jaspreet and C.A.E. Hauser
Laboratory News, (2015)

Keywords:

Peptide hydrogels, Biomedicine, Human body

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2015

In situ synthesis of size-controlled, stable silver nanoparticles within ultrashort peptide hydrogels and their anti-bacterial properties
M.R. Reithofer, A. Lakshmanan, A.T.K. Ping, J.M. Chin and C.A.E. Hauser
Biomaterials, 35 (2014) 7535-7542

Keywords:

Silver, Nanoparticle, Peptide, Hydrogel, Self-assembly, Anti-bacterial

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2014

De novo design and experimental characterization of ultrashort self-associating peptides
J. Smadbeck, K.H. Chan, G.A. Khoury, B. Xue, R.C. Robinson, C.A.E. Hauser, and C.A. Floudas
PLOS Computational Biology 10 [7] (2014) e1003718

Keywords:

Computational protein design, Sequence selection problem, Amyloid fibril formation, Atomic-level accuracy, Mean-field theory, Cross-beta spine, Flexible templates, Combinatorial libraries, Biological-materials, Compstatin variants

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2014

Creation of consistent burn wounds: a rat model
E.Z. Cai, C.H. Ang, A. Raju, K.B. Tan, E.C.H. Hing, Y. Loo, Y.C. Wong, H. Lee, J. Lim, S.M. Moochhala, C.A.E. Hauser, and T.C. Lim
Archives of Plastic Surgery, 41 (2014) 317-324

Keywords:

Animals, Burns, Rats wound healing

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2014

Self-assembled peptide nanostructures for regenerative medicine and biology
M. Ni and C.A.E. Hauser
In Micro- and Nano-Fabrication Using Self-Assembled Biological Nanostructures, J. Castillo-Leon and W. Svendsen ed., Elsevier, 2014

Keywords:

Peptide nanofibers, Peptide nanotubes, Ultrashort peptides, Tissue engineering scaffolds, Drug delivery vehicles, Peptide therapeutics

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2014

Highlight on: P-Glycoprotein-dependent trafficking of nanoparticle-drug conjugates
K.H. Chan and C.A.E. Hauser
Materials View, 2014

Keywords:

P-Glycoprotein-dependent, Nanoparticle-drug conjugates, Nanoparticles,

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2014

Amyloid-based nanosensors and nanodevices
C.A.E. Hauser, S. Maurer-Stroh and I.C. Martins
Chemical Society Reviews, 43 (2014) 5326-45

Keywords:

Fibril-forming segments, Dip-pen nanolithography, X-ray-diffraction, Alzheimers-disease, Peptide nanotubes, Carbon nanotubes, Molecular-basis, Globular-proteins

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2014

Short to ultrashort peptide hydrogels for biomedical uses
W.Y. Seow and C.A.E. Hauser
Materials Today 17 (2014), 381–388

Keywords:

Self-assembling peptide, Beta-sheet tapes, Amphiphile nanofibers, Hyaluronic-acid, Complementary oligopeptide, Mechanical-properties, Gelation properties, Amyloid fibrils, Cell-culture

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2014

Ultrashort peptide nanofibrous hydrogels for the acceleration of healing of burn wounds
Y. Loo, Y.C. Wong, E.Z. Cai, C.H. Ang, A. Raju, A. Lakshmanan, A.G.W. Koh, H.J. Zhou, T.C. Lim, S.M. Moochhala, and C.A.E. Hauser
Biomaterials, 35 (2014) 4805-14

Keywords:

Ultrashort peptide hydrogels, Nanofibers, Self-assembly, Partial thickness burns, Wound healing

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2014

Ligation of anti-cancer drugs to self-assembling ultrashort peptides by click chemistry for localized therapy
M.R. Reithofer, K.-H. Chan, A. Lakshmanan, D.H. Lam, A. Mishra, B. Gopalan, M. Joshi, S. Wang, and C.A.E. Hauser
Chemical Science, 5 (2014) 625-630

Keywords:

Hydrogel matrices, Cancer-chemotherapy, Colorectal-cancer, Targeted delivery, Carbon nanotubes, Controlled-trial, Platinum drugs, Pharmacokinetics

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2014

Influence of metal salts on the hydrogelation properties of ultrashort aliphatic peptides
A. Mishra, K.-H. Chan, M.R. Reithofer, and C.A.E. Hauser
RSC Advances, 3 (2013) 9985-9993

Keywords:

Self-assembling peptide, Hofmeister series, Spectroscopy, Stability, Scaffolds, Coordination, Biomaterials

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2013

Tunable mechanical properties of ultrasmall peptide hydrogels by crosslinking and functionalization to achieve the 3D distribution of cells
W.Y. Seow and C.A.E. Hauser
Advanced Healthcare Materials, 2 (2013) 1219-1223

Keywords:

Ultrasmall peptides, Hydrogel, Disulfide bonds, 3D environment, Crosslinking

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2013

A convenient and minimally-invasive method to study gel formation by surface tension measurements
W.Y. Seow and C.A.E. Hauser
Journal of Chemical Science and Technology, 2 (2013) 88-92

Keywords:

Hydrogel; Gelation Kinetics; Surface Tension; Gel Formation

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2013

Oxidation as a facile strategy to reduce the surface charge and toxicity of polyethyleneimine gene carriers
W.Y. Seow, K. Liang, M. Kurisawa, and C.A.E. Hauser
Biomacromolecules, 14 (2013) 2340-2346

Keywords:

Poly(ethylenimine), Degradation, Efficiency, Peptides, Vector, Cells

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2013

Aliphatic peptides show similar self-assembly to amyloid core sequences, challenging the importance of aromatic interactions in amyloidosis
A. Lakshmanan, D.W. Cheong, A. Accardo, E. Di Fabrizio, C. Riekel, and C.A.E. Hauser
PNAS, 110[2] (2013) 519-524

Keywords:

Fibril formation, Structural-characterization, Polypeptide iapp, Building-blocks, X-ray, Nanostructures, Transthyretin, Oligomers, Proteins

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2013

Peptide hydrogels support stem cell applications in regenerative medicine
C.A.E. Hauser and Y. Loo
Gynäkologische Endokrinologie, 10 (2012) 255-264

Keywords:

Pluripotent stem cells, Embryonic stem cells, Hydrogels, Peptides, Cell culture

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2012

Self-assembling peptides as cell-interactive scaffolds
E.C. Wu, S. Zhang, and C.A.E. Hauser
Advanced Functional Materials, 22[3] (2011) 456-468

Keywords:

Self-assembly, Peptides, Scaffold, Tissue engineering

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2011

Short self-assembling peptides as building blocks for modern nanodevices
A. Lakshmanan, S. Zhang, C.A.E. Hauser
Trends in Biotechnology, 30[3] (2011) 155-165

Keywords:

Ionic-complementary peptide, Nanoparticle superstructures, Nanotechnological applications, Diphenylalanine nanotubes, Amphiphile nanofibers, Modified electrodes, Manipulation

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2011

From short peptides to nanofibers to macromolecular assemblies in biomedicine
Y. Loo, S. Zhang and C.A.E. Hauser
Biotechnology Advances, 30[3] (2011) 593-603

Keywords:

Hydrogels, Self-assembling peptide motifs, Fibril formation, Supramolecular architecture, Regenerative medicine

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2011

Self-Assembling peptide surfactants A6K and A6D Adopt α-helical structures useful for membrane protein stabilization
K. Oglęcka, F. Zhuang, and C.A.E. Hauser
Membranes, 1 (2011) 314-326

Keywords:

Fiber diffraction, Molecular dynamics simulation, Self-assembly mechanism, Supramolecular peptide scaffolds, Ultrasmall peptides

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2011

Ultrasmall peptides self-assemble into diverse nanostructures: morphological evaluation and potential implications
A. Lakshmanan and C.A.E. Hauser
International Journal of Molecular Sciences, 12 (2011) 5736-5746

Keywords:

Ultrasmall peptides, Self-assembly, Bioengineering, Nanotechnology, Supramolecular structures, Origin of life

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2011

The effect of thiol functional group incorporation into cationic helical peptides on antimicrobial activities and spectra
N. Wiradharma, M. Khan, L.-K. Yong, C.A.E. Hauser, S.V. Seow, S. Zhang, Y.-Y. Yang
Biomaterials, 32 (2011) 9100-9108

Keywords:

Antimicrobial peptides (AMP), alpha-Helix, Thiol and sulfhydryl, Membrane lysis, Hemolysis, Drug resistance

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2011

Ultrasmall natural peptides self-assemble to strong temperature-resistant helical fibers in scaffolds suitable for tissue engineering
A. Mishra, Y. Loo, R. Deng, Y.J. Chuah, H.T. Hee, J.Y. Ying and C.A.E. Hauser
NanoToday, 6 (2011) 232-239

Keywords:

Ultrasmall peptides, Self-assembly, Hydrogels, Tissue engineering

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2011

Synthetic cationic amphiphilic α-helical peptides as antimicrobial agents
N. Wiradharma, U. Khoe, C.A.E. Hauser, S.V. Seow, S. Zhang, and Y.Y. Yang
Biomaterials, 32 (2011) 2204-2212

Keywords:

α-Helix, Antimicrobial peptides (AMP), Hemolysis, Membrane lysis, Minimum inhibitory concentration (MIC)

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2011

Natural tri- to hexapeptides self-assemble in water to amyloid β-type fiber aggregates by unexpected α-helical intermediate structures
C.A.E. Hauser, R. Deng, A. Mishra, Y. Loo, (...), A. Accardo, M.B. Sullivan, C. Riekel, J.Y. Ying, and U. Hauser
PNAS, 108 (2011) 1361–1366

Keywords:

Self-assembly mechanism, Ultrasmall peptides, Supramolecular peptide scaffolds, Fiber diffraction, Molecular dynamics simulation

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2011

Peptides as biological semiconductors
C.A.E. Hauser, S. Zhang
Nature, 468 (2010) 516-517

Keywords:

Quantum confinement, Nanotubes

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2010

Designer self-assembling peptide nanofiber biological materials
C.A.E. Hauser, S. Zhang
Chem. Soc. Rev. 39 (2010) 2780-2790

Keywords:

Surfactant-like peptides, Complementary oligopeptide, Beta-sheet, Endothelial-cells, Form nanotubes, In-vitro, scaffolds, Hydrogel, Differentiation, Nanovesicles

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2010

Study of bioengineered zebra fish olfactory receptor 131-2: receptor purification and secondary structure analysis
K.-J. Leck, S. Zhang and C.A.E. Hauser
PLoS One, 5 [11] (2010) 2780-2790

Keywords:

HEK293S tetracyclineinducible system, G protein coupled receptor, Zebra fish receptor

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2010

Molecular self-assembly and applications of designer peptide amphiphiles
X. Zhao, F. Pan, H. Xu, C.A.E. Hauser, S. Zhang, and J.R. Lu
Chem. Soc. Rev. 39 (2010) 3480-3498

Keywords:

Peptide fragments, Biocompatible materials, Nanomaterials, Surface-active agents

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2010

Designer self-assembling peptide materials for diverse applications
C.A.E. Hauser, S. Zhang
Macromol. Symp. 295 (2010) 30-48

Keywords:

3D cell cultures, Ionic self-complementary peptides, Lipid-like peptides, Molecular self-assembly, Stabilizing membrane proteins, Tissue regeneration

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2010

Development of a small molecule peptidomimetic affinity ligand for efficient purification of the large protein factor VIII
S. Knör, B. Laufer, A.V. Khrenov, A. Benhida, S.C. Grailly, N. Beaufort, V. Magdolen, C.A.E. Hauser, E.L. Saenko, J.-M.R. Saint-Remy, H. Kessler
Adv. Exp. Med. Biol., 611 (2009) 151-152

Keywords:

Protein purification, Ligand binding, Protein degradation, Peptides

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2009

Publications