Muhammad Saleem, PhD

​Dr. Saleem is interested in eukaryotic and prokaryotic proteins expression, purification, characterization, and high-resolution structure determination by x-ray crystallography and cryo electron microscopy; Self-assembly of recombinant proteins and peptides for therapeutic applications

• Characterisation of the Immunomodulatory Effects of Meningococcal Opa Proteins on Human Peripheral Blood Mononuclear Cells and CD4+ T Cells
  C. Jones, M. Sadarangani, S. Lewis, I. Payne, M. Saleem, J.P. Derrick and A. Pollard
  PlosOne, 11(4) e0154153, 2016


• Dissection of the function of the RmpM periplasmic protein from Neisseria meningitides
  S. Maharjan, M. Saleem, I.M. Feavers, J.X. Wheeler, R. Care, J.P. Derrick
  Microbiology, 162(2): 364-375, 2016


• PqsBC, a condensing enzyme in the biosynthesis of the Pseudomonas aeruginosa quinolone signal: crystal structure, inhibition, and reaction mechanism
  S.L. Drees, C. Li, F. Prasetya, M. Saleem, I. Dreveny, P. Williams, U. Hennecke, J. Emsley, and S. Fetzner
  Journal of Biological Chemistry 291(13): 6610-6624, 2016


• Structures of NCS-1 complexes with the D2 dopamine receptor and GPCR kinase 1 (GRK1) peptides shows different modes of interactions
  S. Pandalaneni, V. Karuppiah, M. Saleem, L.P. Haynes, R.D. Burgoyne, O. Mayans, J.P. Derrick, and L.Y. Lian
  Journal of Biological Chemistry, 290(30): 18744-18756, 2015


• N. meningitidis native outer membrane vesicles containing modified LPS have an adjuvant effect for meningococcal, non-meningococcal proteins, and polysaccharide antigens
  J.C. Nagaputra, C. Rollier, M. Sadarangani, J.C. Hoe, O. Mehta, G. Norheim, M. Saleem, J.P. Derrick, H. Chan I. Feavers, A. Pollard, E.R. Moxon
  Clinical and Vaccine immunology, 21(2): 234-242, 2014


• Use of a molecular decoy to segregate transport from antigenicity in the FrpB iron transporter from Neisseria meningitides
  M. Saleem, S.M. Prince, S. Rigby, M. Imran, H. Sanders, H. Patel, H. Chan, I.M. Feavers and J.P. Derrick
  PlosOne, 8(2) e56746, 2013


• Refolding, purification and crystallization of the FrpB outer membrane iron transporter from Neisseria meningitides
  M. Saleem, S.M. Prince, H. Patel, H. Chan, I.M. Feavers and J.P. Derrick
  Acta Crystallographica, F68: 231-235, 2012


• Expression, purification, and crystallization of Neisserial outer membrane proteins
  M. Saleem, J. Moore and J.P. Derrick
  Methods in Molecular Biology. 799: 91-106, 2012


• Purification and 3-D electron microscopy structure of the Neisseria meningitides type IV pilus biogenesis protein PilG
  R.F. Collins, M. Saleem and J.P. Derrick
  Journal of Bacteriology 189: 6389-6396 2007

• ​Ph.D., Biomolecular sciences, The University of Manchester, U.K., 2008
• M.Phil., Biotechnology, National Institute for Biotechnology and Genetic Engineering (NIBGE), Pakistan, 2004
• M.Sc., Chemistry, University of the Punjab, Pakistan, 2002
• B.Sc., Chemistry, Zoology University of the Punjab, Pakistan, 1999

• ​2017 –Present: Postdoctoral Fellow, King Abdullah University of Science and Technology (KAUST), Saudi Arabia
• 2016 – 2017: Postdoctoral Research Fellow, University of Nottingham, U.K.
• 2013 – 2015: Postdoctoral Research Fellow, University of Leeds, U.K.
• 2008 – 2013: Postdoctoral Research Fellow, University of Manchester, U.K

• ​British crystallographic association, BCA
• Society of general microbiology, SG

• ​2005-2008 BBSRC and The University of Manchester UK scholarship for PhD

• Computational Bioscience Research Center
• Biological and Environmental Science and Engineering Division