Muhammad Saleem, PhD

Postdoctoral Fellows



B2/L4 - 4216-WS07

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Research Interests

​Dr. Saleem is interested in eukaryotic and prokaryotic proteins expression, purification, characterization, and high-resolution structure determination by x-ray crystallography and cryo electron microscopy; Self-assembly of recombinant proteins and peptides for therapeutic applications

Selected Publications

  • Characterisation of the Immunomodulatory Effects of Meningococcal Opa Proteins on Human Peripheral Blood Mononuclear Cells and CD4+ T Cells
    C. Jones, M. Sadarangani, S. Lewis, I. Payne, M. Saleem, J.P. Derrick and A. Pollard
    PlosOne, 11(4) e0154153, 2016

  • Dissection of the function of the RmpM periplasmic protein from Neisseria meningitides
    S. Maharjan, M. Saleem, I.M. Feavers, J.X. Wheeler, R. Care, J.P. Derrick
    Microbiology, 162(2): 364-375, 2016

  • PqsBC, a condensing enzyme in the biosynthesis of the Pseudomonas aeruginosa quinolone signal: crystal structure, inhibition, and reaction mechanism
    S.L. Drees, C. Li, F. Prasetya, M. Saleem, I. Dreveny, P. Williams, U. Hennecke, J. Emsley, and S. Fetzner
    Journal of Biological Chemistry 291(13): 6610-6624, 2016

  • Structures of NCS-1 complexes with the D2 dopamine receptor and GPCR kinase 1 (GRK1) peptides shows different modes of interactions
    S. Pandalaneni, V. Karuppiah, M. Saleem, L.P. Haynes, R.D. Burgoyne, O. Mayans, J.P. Derrick, and L.Y. Lian
    Journal of Biological Chemistry, 290(30): 18744-18756, 2015

  • N. meningitidis native outer membrane vesicles containing modified LPS have an adjuvant effect for meningococcal, non-meningococcal proteins, and polysaccharide antigens
    J.C. Nagaputra, C. Rollier, M. Sadarangani, J.C. Hoe, O. Mehta, G. Norheim, M. Saleem, J.P. Derrick, H. Chan I. Feavers, A. Pollard, E.R. Moxon
    Clinical and Vaccine immunology, 21(2): 234-242, 2014

  • Use of a molecular decoy to segregate transport from antigenicity in the FrpB iron transporter from Neisseria meningitides
    M. Saleem, S.M. Prince, S. Rigby, M. Imran, H. Sanders, H. Patel, H. Chan, I.M. Feavers and J.P. Derrick
    PlosOne, 8(2) e56746, 2013

  • Refolding, purification and crystallization of the FrpB outer membrane iron transporter from Neisseria meningitides
    M. Saleem, S.M. Prince, H. Patel, H. Chan, I.M. Feavers and J.P. Derrick
    Acta Crystallographica, F68: 231-235, 2012

  • Expression, purification, and crystallization of Neisserial outer membrane proteins
    M. Saleem, J. Moore and J.P. Derrick
    Methods in Molecular Biology. 799: 91-106, 2012

  • Purification and 3-D electron microscopy structure of the Neisseria meningitides type IV pilus biogenesis protein PilG
    R.F. Collins, M. Saleem and J.P. Derrick
    Journal of Bacteriology 189: 6389-6396 2007


  • ​Ph.D., Biomolecular sciences, The University of Manchester, U.K., 2008
  • M.Phil., Biotechnology, National Institute for Biotechnology and Genetic Engineering (NIBGE), Pakistan, 2004
  • M.Sc., Chemistry, University of the Punjab, Pakistan, 2002
  • B.Sc., Chemistry, Zoology University of the Punjab, Pakistan, 1999

Professional Profile

  • ​2017 –Present: Postdoctoral Fellow, King Abdullah University of Science and Technology (KAUST), Saudi Arabia
  • 2016 – 2017: Postdoctoral Research Fellow, University of Nottingham, U.K.
  • 2013 – 2015: Postdoctoral Research Fellow, University of Leeds, U.K.
  • 2008 – 2013: Postdoctoral Research Fellow, University of Manchester, U.K

Scientific and Professional Membership

  • ​British crystallographic association, BCA
  • Society of general microbiology, SG


  • ​2005-2008 BBSRC and The University of Manchester UK scholarship for PhD

Research Interests Keywords

Biotherapeutic Bioengineering Vaccine development

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King Abdullah bin Abdulaziz Al Saud, 1924 – 2015

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