Ligation of anti-cancer drugs to self-assembling ultrashort peptides by click chemistry for localized therapy
M.R. Reithofer, K.-H. Chan, A. Lakshmanan, D.H. Lam, A. Mishra, B. Gopalan, M. Joshi, S. Wang, and C.A.E. Hauser
Chemical Science, 5 (2014) 625-630
Self-assembling ultrashort peptides from aliphatic amino acids were functionalized with platinum anticancer drugs by click chemistry. Oxaliplatin-derived hybrid peptide hydrogels with up to 40% drug loading were tested for localized breast cancer therapy. Stably injected gels showed significant tumor growth inhibition in mice and a better tolerance compared to the free platinum drug.
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