​Probing droplets with biological colloidal suspensions on smart surfaces by synchrotron radiation micro- and nano-beams

Droplets with colloidal biological suspensions evaporating on substrates with defined wetting properties generate confined environments for initiating aggregation and self-assembly processes. We describe smart micro- and nanostructured surfaces, optimized for probing single droplets and residues by synchrotron radiation micro- and nanobeam diffraction techniques. Applications are presented for Ac-IVD and β-amyloid (1-42) peptides capable of forming cross-β sheet structures. Complementary synchrotron radiation FTIR microspectroscopy addresses secondary structure formation. The high synchrotron radiation source brilliance enables fast raster-scan experiments.

DOI: 10.1016/j.optlaseng.2015.03.004

Biological colloids Digital microfluidics Micro-/nano X-ray diffraction MicroFTIR Synchrotron radition