"What doesn't kill you makes you stronger": future applications of amyloid aggregates in biomedicine
S. Abdelrahman, M. Alghrably, J.I. Lachowicz, A.-H. Emwas, C.A.E. Hauser, M. Jaremko
Molecules (Basel, Switzerland) Open Access, Volume 25, Issue 22, 2020
Amyloid proteins are linked to the pathogenesis of several diseases including Alzheimer’s disease, but at the same time a range of functional amyloids are physiologically important in humans. Although the disease pathogenies have been associated with protein aggregation, the mechanisms and factors that lead to protein aggregation are not completely understood. Paradoxically, unique characteristics of amyloids provide new opportunities for engineering innovative materials with biomedical applications. In this review, we discuss not only outstanding advances in biomedical applications of amyloid peptides, but also the mechanism of amyloid aggregation, factors affecting the process, and core sequences driving the aggregation. We aim with this review to provide a useful manual for those who engineer amyloids for innovative medicine solutions.
"KAUST shall be a beacon for peace, hope and reconciliation, and shall serve the people of the Kingdom and the world."
King Abdullah bin Abdulaziz Al Saud, 1924 – 2015
Thuwal 23955-6900, Kingdom of Saudi Arabia
Al-Haytham Building (Bldg. 2)