Professor Charlotte A. E. Hauser

Professor Hauser’s research interests align at the interfaces between chemistry, biomedicine, bioengineering and nanotechnology. Focus is on the development of platform technologies, using smart nanomaterials for regenerative, biomedical and environmental applications.
Her interest refers to the rational molecular design, synthesis and mechanistic understanding of novel supramolecular structures. Investigated systems include peptide-based nanostructures with an innate propensity to self-assemble to biomimetic architectures applicable for biomedical applications such as cell substrates, sensors and 3D tissue scaffolds for regenerative medicine. Bottom-up nanofabrication is a powerful tool for the development of functional tissue equivalents, organotypic tissues and devices. Moreover, these biomimetic supramolecular constructs will be used for the design and fabrication of novel organ-on-a-chip devices and disease models.
Furthermore, Professor Hauser is interested in 3D bioprinting, using supramolecular organotypic constructs to fabricate high-throughput platforms for drug screening, pathogen detection and other diagnostic purposes. Synthetic biology approaches are explored for the generation of functional biomaterial.

• A chemically well-defined, self-assembling 3D substrate for long-term culture of human pluripotent stem cells. Y. Loo, Y.S. Chan, I. Szczerbinska, B.C.P. Tan, A.C.A. Wan, H.H. Ng, C.A.E. Hauser. ACS Appl. Bio Mater., 2, 4, 1406-1412, 2019

   

• Optimization of a 3D bioprinting process using ultrashort peptide bioinks. Z. Khan, K. Kahin, S. Rauf, G. Ramirez-Calderon, N. Papagiannis, M. Abdulmajid, C.A.E. Hauser. International Journal of Bioprinting 5(1),173, 2019

   

• Novel ultrashort self-assembling peptide bioinks for 3d culture of muscle myoblast cells. W. Arab, S. Rauf, O. Al-Harbi, C. Hauser. Open Journal Systems, 2018

   

• C-Terminal residue of ultrashort peptides impacts on molecular self-assembly, hydrogelation, and interaction with small-molecule drugs. K.H. Chan, W.H. Lee, M. Ni, Y. Loo & C.A.E. Hauser. Scientific Reports, Volume 8, Article number: 17127, 2018

   

• ​Towards biologically relevant synthetic designer matrices in 3D bioprinting for tissue engineering and regenerative medicine. R.M. Costa, S. Rauf, C.A.E. Hauser. Current Opinion in Biomedical Engineering, Volume 2, Pages 90-98, 2017​

   
• ​Peptide Bioink: Self-Assembling Nanofibrous Scaffolds for Three-Dimensional Organotypic Cultures. Y. Loo, A. Lakshmanan, M. Ni, L.L. Toh, S. Wang and C.A.E. Hauser. Nano Letters, 15 (2015) 6919-6925

• Ultrashort Peptide Nanofibrous Hydrogels for the Acceleration of Healing of Burn Wounds. Y. Loo, Y.C. Wong, E.Z. Cai, C.H. Ang, A. Raju, A. Lakshmanan, A.G. Koh, H.J. Zhou, T.C. Lim, S.M. Moochhala and C.A.E. Hauser. Biomaterials, 35 (2014) 4805-4814

 

• In situ Synthesis of Size-Controlled, Stable Silver Nanoparticles within Ultrashort Peptide Hydrogels and their Anti-Bacterial Properties.M.R. Reithofer, A. Lakshmanan, A.T.K. Ping, J.M. Chin and C.A.E. Hauser. Biomaterials, 35 (2014) 7535-7542

 

• Ligation of Anti-Cancer Drugs to Self-Assembling Ultrashort Peptides by Click Chemistryfor Localized Therapy. M.R. Reithofer, K.H. Chan, A. Lakshmanan, D.H. Lam, A. Mishra, B. Gopalan, M. Joshi, S. Wang, and C.A.E. Hauser. Chemical Science, 5 (2014) 625-630




• Tunable Mechanical Properties of Ultrasmall Peptide Hydrogels by Crosslinking and Functionalization to Achieve the 3D Distribution of Cells. W.Y. Seow and C.A.E. Hauser. Advanced Healthcare Materials, 2 (2013) 1219-1223

 

• Aliphatic Peptides Show Similar Self-Assembly to Amyloid Core Sequences, Challenging the Importance of Aromatic Interactions in Amyloidosis. A. Lakshmanan, D.W. Cheong, A. Accardo, E. Di Fabrizio, C. Riekel, and C.A.E. Hauser. Proceedings of the National Academy of Sciences, 110 (2013) 519-524

 

• ​Ph.D., University of Cologne, Germany, 1990
  
• M.Sc., Chemistry, University of Cologne, 1986
  
• B.Sc., Chemistry, University of Cologne, Germany, 1983
  
• B.Sc., Physics, University of Cologne, Germany,1980​
  

• First Program: Bioscience 

• Second Program: Material Science and Engineering 

• Third Program: Chemical and Biological Engineering